Description

2-Hydroxy-4-(Trifluoromethyl)Pyridine-3-Carbonitrile is a high-value, multi-functional heterocyclic building block characterized by its pyridine core, hydroxyl group, nitrile, and trifluoromethyl substituent. This unique combination of functional groups makes it a critical intermediate for the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists in the life sciences sector for constructing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially in kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Precursor: Serves as a building block for functionalized ligands in catalysis and for creating specialty polymers with tailored electronic or surface properties.
• Chemical Research & Development: Employed in academic and industrial labs for method development, library synthesis, and exploring new chemical spaces in medicinal chemistry.
• Fluorine Chemistry: An important compound for introducing the trifluoromethyl group into complex molecular architectures, a common motif in modern drug design.

Basic Information

Product Name	2-Hydroxy-4-(Trifluoromethyl)Pyridine-3-Carbonitrile
CAS No.	1261268-77-2
Molecular Formula	C7H3F3N2O
Molecular Weight	188.11 g/mol
Synonyms	3-Cyano-2-hydroxy-4-(trifluoromethyl)pyridine; 4-(Trifluoromethyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile; 2-Hydroxy-4-trifluoromethylnicotinonitrile; 2-Hydroxy-4-(trifluoromethyl)nicotinonitrile; 2-Oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile; 4-Trifluoromethyl-2-hydroxynicotinonitrile; 2-Hydroxy-4-(trifluoromethyl)-3-pyridinecarbonitrile
EINECS	Contact for details

Quality Control

Our 2-Hydroxy-4-(Trifluoromethyl)Pyridine-3-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent identity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound may be light-sensitive and hygroscopic; prolonged exposure to light, moisture, or extreme temperatures should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.