Description

tert-Butyl 4-(Hydroxymethyl)-4-(Trifluoromethyl)Piperidine-1-Carboxylate is a high-value, multi-functional piperidine derivative and a crucial protected intermediate in modern synthetic chemistry. Its core value lies in providing a versatile scaffold for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require a reliable, high-purity building block for sophisticated synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and metabolic disease targets.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides, leveraging the trifluoromethyl group for enhanced bioactivity.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the creation of specialty polymers and advanced organic materials with unique properties.
• Chemical Biology Probes: Utilized as a scaffold for developing molecular probes to study biological pathways and enzyme functions.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	tert-Butyl 4-(Hydroxymethyl)-4-(Trifluoromethyl)Piperidine-1-Carboxylate
CAS No.	1260893-18-2
Molecular Formula	C12H20F3NO3
Molecular Weight	283.29 g/mol
Synonyms	1-Boc-4-(hydroxymethyl)-4-(trifluoromethyl)piperidine; 4-(Hydroxymethyl)-4-(trifluoromethyl)piperidine-1-carboxylic acid tert-butyl ester; N-Boc-4-(hydroxymethyl)-4-(trifluoromethyl)piperidine; tert-Butyl 4-(hydroxymethyl)-4-(trifluoromethyl)-1-piperidinecarboxylate; 1-(tert-Butoxycarbonyl)-4-(hydroxymethyl)-4-(trifluoromethyl)piperidine; Boc-4-(hydroxymethyl)-4-(trifluoromethyl)piperidine; 4-(Trifluoromethyl)-4-piperidinemethanol, 1-Boc protected
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(Hydroxymethyl)-4-(Trifluoromethyl)Piperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing identity, purity, and impurity profiles. Our production adheres to cGMP principles where applicable, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.