Description

4-Chloro-6-(Trifluormethyl)Pyridine-3-Ol CAS NO 1260890-17-2 is a high-purity, halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. This compound matters for its unique trifluoromethyl and chloro substituents, which are key to modulating the electronic and steric properties of target molecules, thereby enhancing their biological activity and metabolic stability. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting CNS disorders, inflammation, and infectious diseases.
• Agrochemical Intermediate: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group is prized for its lipophilicity and stability.
• Material Science Research: Serves as a precursor for creating functionalized ligands, catalysts, and monomers used in specialty polymers and advanced materials.
• Chemical Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to introduce complex pyridine motifs.
• Life Science Research: Utilized as a probe or scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and hit-to-lead optimization.

Basic Information

Product Name	4-Chloro-6-(Trifluormethyl)Pyridine-3-Ol
CAS No.	1260890-17-2
Molecular Formula	C6H3ClF3NO
Molecular Weight	197.54 g/mol
Synonyms	3-Hydroxy-4-chloro-6-(trifluoromethyl)pyridine; 4-Chloro-6-(trifluoromethyl)pyridin-3-ol; 4-Chloro-6-(trifluoromethyl)-3-pyridinol; 4-Chloro-6-trifluoromethyl-3-pyridinol; 4-Chloro-6-trifluoromethylpyridin-3-ol; 4-Chloro-6-(trifluoromethyl)-3-hydroxypyridine; 3-Pyridinol, 4-chloro-6-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 4-Chloro-6-(Trifluormethyl)Pyridine-3-Ol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.