Description

3-Bromo-5-Chloro-1,8-Naphthyridine is a high-purity, multi-halogenated heterocyclic building block of significant interest in advanced organic synthesis. Its unique fused-ring structure, functionalized with distinct halogen atoms, makes it a versatile and valuable precursor for constructing complex molecular architectures. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in kinase inhibitor and antiviral research programs.
• Agrochemical Synthesis: Serves as a core structure for creating novel herbicides, fungicides, and insecticides with enhanced activity.
• Material Science Precursor: Used in the synthesis of organic semiconductors, ligands for metal-organic frameworks (MOFs), and specialty dyes.
• Cross-Coupling Reactions: The bromo and chloro substituents offer orthogonal reactivity for sequential Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions.
• Chemical Biology Probes: Acts as a scaffold for developing molecular probes and tags used in biochemical and diagnostic applications.
• Academic & Contract Research: Essential for methodological studies in heterocyclic and medicinal chemistry within university and CRO laboratories.

Basic Information

Product Name	3-Bromo-5-Chloro-1,8-Naphthyridine
CAS No.	1260815-70-0
Molecular Formula	C8H4BrClN2
Molecular Weight	257.49 g/mol
Synonyms	3-Bromo-5-chloro-1,8-naphthyridine; 5-Chloro-3-bromo-1,8-naphthyridine; 1,8-Naphthyridine, 3-bromo-5-chloro-; 3-Bromo-5-chloro-[1,8]naphthyridine
EINECS	Contact for details

Quality Control

Every batch of 3-Bromo-5-Chloro-1,8-Naphthyridine is manufactured under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency meet the exacting standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.