Description

8-Amino-5-Aza-Spiro[2.5]Octane-5-Carboxylic Acid tert-Butyl Ester is a high-value, nitrogen-containing spirocyclic building block. This compound is critical for medicinal chemistry research and development, offering a rigid, three-dimensional scaffold that is essential for modulating the pharmacokinetic and pharmacodynamic properties of new drug candidates. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers specializing in the synthesis of novel active pharmaceutical ingredients (APIs) and complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates targeting central nervous system (CNS) disorders, infectious diseases, and oncology.
• Medicinal Chemistry Research: Used in scaffold-hopping and structure-activity relationship (SAR) studies to explore new chemical space and improve drug-like properties.
• Protease Inhibitor Development: The spirocyclic structure and amino functionality make it a valuable precursor for designing potent enzyme inhibitors.
• Peptidomimetic Synthesis: Serves as a constrained, non-natural amino acid analog for creating stable peptide mimics with enhanced metabolic stability.
• Chemical Biology Probes: Employed in the development of tool compounds and molecular probes for target identification and validation in biological systems.
• Agrochemical Research: Potential intermediate in the development of new crop protection agents with novel modes of action.

Basic Information

Product Name	8-Amino-5-Aza-Spiro[2.5]Octane-5-Carboxylic Acid tert-Butyl Ester
CAS No.	1260802-34-3
Molecular Formula	C11H20N2O2
Molecular Weight	212.29 g/mol
Synonyms	tert-Butyl 8-amino-5-azaspiro[2.5]octane-5-carboxylate; 5-Azaspiro[2.5]octane-5-carboxylic acid, 8-amino-, 1,1-dimethylethyl ester; 8-Amino-5-azaspiro[2.5]octane-5-carboxylic acid 1,1-dimethylethyl ester; 5-tert-Butoxycarbonyl-8-amino-5-azaspiro[2.5]octane; 8-Amino-5-Boc-5-azaspiro[2.5]octane; Boc-8-Amino-5-azaspiro[2.5]octane; (8-Amino-5-azaspiro[2.5]octan-5-yl)(tert-butoxy)methanone
EINECS	Contact for details

Quality Control

Our 8-Amino-5-Aza-Spiro[2.5]Octane-5-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (nitrogen or argon) after opening to prevent degradation. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.