Description

1-(5-Bromopyridin-2-Yl)-2-Chloroethanone is a high-purity, halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. Its unique bifunctional structure, featuring both bromo and chloro substituents, makes it a versatile and valuable intermediate for constructing complex molecular architectures. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides, leveraging its reactive halogen sites.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized pyridine-based ligands used in transition metal catalysis.
• Material Science Research: Employed in the synthesis of organic electronic materials and functional polymers.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions due to the bromopyridyl moiety.
• Nucleophilic Substitution: The chloroacetyl group is reactive towards various nucleophiles, enabling further functionalization.

Basic Information

Product Name	1-(5-Bromopyridin-2-Yl)-2-Chloroethanone
CAS No.	1260759-84-9
Molecular Formula	C7H5BrClNO
Molecular Weight	234.48 g/mol
Synonyms	2-Chloro-1-(5-bromo-2-pyridinyl)ethanone; 5-Bromo-2-chloroacetylpyridine; 1-(5-Bromo-2-pyridinyl)-2-chloroethanone; 2-Chloro-1-(5-bromopyridin-2-yl)ethan-1-one; 5-Bromo-2-pyridyl chloro ketone; α-Chloro-5-bromopicolinophenone; (5-Bromopyridin-2-yl)(chloro)methanone
EINECS	Contact for details

Quality Control

Every batch of 1-(5-Bromopyridin-2-Yl)-2-Chloroethanone is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high standards required for research and process chemistry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and other relevant techniques is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.