Description

5-Bromo-1,2,3,4-Tetrahydro-2,7-Naphthyridin-1-One is a high-purity, advanced pharmaceutical intermediate characterized by its brominated naphthyridine core structure. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with targeted biological activity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to explore novel chemical space and improve drug-like properties.
• Organic Synthesis Building Block: Serves as a versatile precursor for further functionalization via cross-coupling reactions, nucleophilic substitutions, and other transformations.
• Biochemical Tool Compound: Potential use in the development of chemical probes for studying biological pathways and target validation in vitro.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis and scale-up projects under cGMP conditions.

Basic Information

Product Name	5-Bromo-1,2,3,4-Tetrahydro-2,7-Naphthyridin-1-One
CAS No.	1260666-73-6
Molecular Formula	C8H7BrN2O
Molecular Weight	227.06 g/mol
Synonyms	5-Bromo-1,2,3,4-tetrahydro-2,7-naphthyridin-1-one; 5-Bromo-1,2,3,4-tetrahydro-2,7-naphthyridinone; 5-Bromo-1,2,3,4-tetrahydro-2,7-naphthyridin-1(2H)-one; 5-Bromotetrahydro-2,7-naphthyridin-1-one; 1260666-73-6; 5-Bromo-1,2,3,4-tetrahydro-2,7-naphthyridine-1-one; 5-Bromo-1,2,3,4-tetrahydro-2,7-naphthyridin-1(2H)-one
EINECS	Contact for details

Quality Control

Our 5-Bromo-1,2,3,4-Tetrahydro-2,7-Naphthyridin-1-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), identity confirmation, and impurity profile is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.