Description

3-Bromo-2-Fluoro-6-Iodopyridine is a high-purity, multi-halogenated pyridine derivative serving as a versatile and critical building block in advanced organic synthesis. Its unique halogen substitution pattern makes it an indispensable intermediate for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and functional materials. This compound is primarily targeted at research and development chemists, process chemists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality intermediates for their synthetic pipelines.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially for kinase inhibitors, antiviral agents, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides, fungicides, and pesticides with enhanced efficacy.
• Ligand and Catalyst Development: Serves as a scaffold for creating sophisticated ligands used in transition metal catalysis and organocatalysis.
• Material Science: Employed in the synthesis of organic electronic materials, such as charge-transport layers or emissive materials for OLEDs.
• Cross-Coupling Reactions: An excellent substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) due to the presence of bromo and iodo leaving groups.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological processes and target engagement.

Basic Information

Product Name	3-Bromo-2-Fluoro-6-Iodopyridine
CAS No.	1260665-99-3
Molecular Formula	C5H2BrFIN
Molecular Weight	301.88 g/mol
Synonyms	2-Fluoro-3-bromo-6-iodopyridine; 6-Iodo-3-bromo-2-fluoropyridine; 3-Bromo-2-fluoro-6-iodopyridine; Pyridine, 3-bromo-2-fluoro-6-iodo-; 1260665-99-3
EINECS	Contact for details

Quality Control

Our 3-Bromo-2-Fluoro-6-Iodopyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled under an inert atmosphere for long-term storage to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.