Description

4-Boc-7-Bromo-1,2,3,5-Tetrahydro-Benzo[E][1,4]Diazepine-3-Carboxylic Acid 3-Methyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a protected diazepine core with a bromo substituent. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel bioactive molecules. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing central nervous system (CNS) and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel benzodiazepine and diazepine-based drug candidates for CNS disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its reactive bromo and protected amine functionalities.
• Custom Synthesis Building Block: Employed in the construction of complex heterocyclic libraries for high-throughput screening in drug discovery.
• API Development: Serves as a critical intermediate in the multi-step synthesis of potential Active Pharmaceutical Ingredients (APIs).
• Chemical Biology Probes: Can be utilized to develop molecular probes for studying biological targets and pathways.

Basic Information

Product Name	4-Boc-7-Bromo-1,2,3,5-Tetrahydro-Benzo[E][1,4]Diazepine-3-Carboxylic Acid 3-Methyl Ester
CAS No.	1260641-27-7
Molecular Formula	C₁₈H₂₃BrN₂O₄
Molecular Weight	411.29 g/mol
Synonyms	7-Bromo-4-[(tert-butoxy)carbonyl]-1,2,3,5-tetrahydrobenzo[e][1,4]diazepine-3-carboxylic acid methyl ester; Methyl 7-bromo-4-[(tert-butoxycarbonyl)amino]-2,3-dihydro-1H-benzo[e][1,4]diazepine-3-carboxylate; 4-Boc-7-bromo-1,2,3,5-tetrahydrobenzo[e][1,4]diazepine-3-carboxylic acid methyl ester; 1260641-27-7; 7-Bromo-4-Boc-1,2,3,5-tetrahydro-benzo[e][1,4]diazepine-3-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our 4-Boc-7-Bromo-1,2,3,5-Tetrahydro-Benzo[E][1,4]Diazepine-3-Carboxylic Acid 3-Methyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.