Description

Methyl 2-(tert-Butoxycarbonylamino)-5,5-Difluoropentanoate is a high-value, protected amino acid derivative featuring a difluoromethylene group, which is critical for modulating the physicochemical and metabolic properties of target molecules. This compound serves as a sophisticated key chiral building block in modern organic synthesis, particularly for the development of novel pharmaceuticals and bioactive compounds. It is primarily utilized by research institutions and pharmaceutical companies engaged in peptidomimetic drug discovery, protease inhibitor design, and the synthesis of fluorinated analogs to enhance drug potency and stability.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of fluorinated peptide analogs and protease inhibitors for therapeutic applications.
• Peptidomimetics Research: Used to incorporate the difluoromethylene unit into peptide backbones, mimicking natural amino acids while improving metabolic stability and bioavailability.
• Medicinal Chemistry: Serves as a versatile building block for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs).
• Agrochemical Synthesis: Potential intermediate in the creation of advanced, fluorinated active ingredients for crop protection.
• Chemical Biology Probes: Enables the synthesis of fluorinated probes for studying enzyme mechanisms and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	Methyl 2-(tert-Butoxycarbonylamino)-5,5-Difluoropentanoate
CAS No.	1260640-64-9
Molecular Formula	C11H19F2NO4
Molecular Weight	267.27 g/mol
Synonyms	Boc-5,5-difluoronorleucine methyl ester; Methyl (2S)-2-[(tert-butoxy)carbonylamino]-5,5-difluoropentanoate; (S)-Methyl 2-((tert-butoxycarbonyl)amino)-5,5-difluoropentanoate; Boc-Difluoronorleucine-OMe; 2-[(tert-Butoxycarbonyl)amino]-5,5-difluoropentanoic acid methyl ester; 5,5-Difluoro-N-Boc-norleucine methyl ester; N-Boc-5,5-difluoronorleucine methyl ester
EINECS	Contact for details

Quality Control

Our production of Methyl 2-(tert-Butoxycarbonylamino)-5,5-Difluoropentanoate adheres to stringent quality protocols suitable for pharmaceutical R&D. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided, detailing results from HPLC, NMR, and MS. We support compliance with ICH guidelines for stability and impurity profiling, and specifications can be aligned with customer-specific requirements for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.