Description

(R)-2-(Pyrrolidin-3-Yloxy)Pyridine Dihydrochloride is a high-purity chiral building block and pharmaceutical intermediate. This compound is of significant value for research and development in medicinal chemistry, particularly in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily needed by pharmaceutical R&D laboratories, contract research and manufacturing organizations (CROs/CMOs), and academic institutions focused on drug discovery, especially for targets involving nicotinic receptors or requiring specific stereochemistry.

Application

• Pharmaceutical Intermediate: Key chiral synthon in the research-scale synthesis of potential therapeutic agents.
• Medicinal Chemistry Research: Used as a building block for constructing complex molecules in drug discovery programs, particularly for central nervous system (CNS) targets.
• Ligand and Probe Development: Serves as a precursor for developing selective ligands for biological studies and diagnostic probes.
• Asymmetric Synthesis: Utilized in catalytic and stoichiometric asymmetric reactions to introduce the (R)-configured pyrrolidinyloxy pyridine moiety.
• Reference Standard: Can be used as an analytical standard for quality control and method development in API manufacturing.

Basic Information

Product Name	(R)-2-(Pyrrolidin-3-Yloxy)Pyridine Dihydrochloride
CAS No.	1260613-92-0
Molecular Formula	C9H14Cl2N2O
Molecular Weight	237.13 g/mol
Synonyms	(R)-2-((3-Pyrrolidinyl)oxy)pyridine dihydrochloride; (R)-2-(3-Pyrrolidinyloxy)pyridine hydrochloride (1:2); Pyridine, 2-[(3R)-3-pyrrolidinyloxy]-, dihydrochloride; (R)-2-(Pyrrolidin-3-yloxy)pyridine 2HCl; (R)-2-(3-Pyrrolidinol)pyridine dihydrochloride
EINECS	Contact for details

Quality Control

Our (R)-2-(Pyrrolidin-3-Yloxy)Pyridine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, chiral HPLC) are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.