Description

1-tert-Butyl 2-Methyl (2R)-Azetidine-1,2-Dicarboxylate CAS NO 1260593-39-2 is a high-purity, chiral azetidine derivative serving as a critical building block in advanced organic synthesis. Its primary value lies in providing a protected, stereodefined azetidine scaffold essential for constructing complex molecules with high enantiomeric purity. This compound is particularly vital for pharmaceutical R&D and process chemistry teams developing novel active pharmaceutical ingredients (APIs), especially in therapeutic areas targeting the central nervous system and metabolic diseases.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of novel drug candidates, particularly in medicinal chemistry programs.
• API Development: Used in the research and scale-up production of Active Pharmaceutical Ingredients requiring the azetidine pharmacophore.
• Asymmetric Synthesis: Employed as a starting material or intermediate in stereoselective reactions to introduce the (2R)-azetidine moiety.
• Protease Inhibitor Research: Building block for compounds targeting serine and cysteine proteases.
• Ligand and Catalyst Preparation: Precursor for chiral ligands used in asymmetric catalysis.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological pathways.

Basic Information

Item	Details
Product Name	1-tert-Butyl 2-Methyl (2R)-Azetidine-1,2-Dicarboxylate
CAS No.	1260593-39-2
Molecular Formula	C11H19NO4
Molecular Weight	229.27 g/mol
Synonyms	(2R)-1-(tert-Butoxycarbonyl)-2-(methoxycarbonyl)azetidine; (R)-1-Boc-2-(methoxycarbonyl)azetidine; (R)-1-(tert-Butoxycarbonyl)azetidine-2-carboxylic Acid Methyl Ester; Methyl (R)-1-Boc-azetidine-2-carboxylate; (R)-Methyl 1-Boc-azetidine-2-carboxylate; 1-Boc-2-(methoxycarbonyl)-(2R)-azetidine; (2R)-Azetidine-1,2-dicarboxylic acid 1-tert-butyl 2-methyl ester
EINECS	Contact for details

Quality Control

Our 1-tert-Butyl 2-Methyl (2R)-Azetidine-1,2-Dicarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure compliance with high-purity standards for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.