Description

n-Fmoc-R-4-Methoxyphenylglycine CAS NO 1260593-18-7 is a high-purity, protected amino acid derivative essential for modern solid-phase peptide synthesis (SPPS). This compound serves as a critical building block for the controlled introduction of the unique R-4-methoxyphenylglycine residue, enabling the creation of complex peptides with specific structural and functional properties. It is primarily utilized by research institutions, pharmaceutical developers, and biotechnology companies engaged in drug discovery, proteomics research, and the development of novel therapeutic peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental reagent for the automated, stepwise construction of custom peptide sequences.
• Pharmaceutical Research & Development: Used in the synthesis of peptide-based drug candidates, including hormone analogs, enzyme inhibitors, and targeted therapeutics.
• Peptidomimetic Design: Incorporation of the 4-methoxyphenylglycine side chain to modulate peptide stability, bioavailability, and receptor binding affinity.
• Chemical Biology & Proteomics: Synthesis of labeled peptides, activity-based probes, and substrates for studying enzyme mechanisms and protein-protein interactions.
• Antibiotic Development: Potential use in constructing novel peptide antibiotics where non-natural amino acids are required to overcome resistance.
• Material Science: Research into bio-inspired materials and peptide-based polymers where specific side-chain functionality is needed.

Basic Information

Item	Detail
Product Name	n-Fmoc-R-4-Methoxyphenylglycine
CAS No.	1260593-18-7
Molecular Formula	C24H21NO5
Molecular Weight	403.43 g/mol
Synonyms	Fmoc-(R)-4-Methoxyphenylglycine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(4-methoxyphenyl)acetic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-methoxy-D-phenylglycine; Fmoc-D-4-Methoxyphenylglycine; Fmoc-4-MeO-Phg-OH; N-α-Fmoc-D-4-methoxyphenylglycine; (R)-2-(Fmoc-amino)-2-(4-methoxyphenyl)acetic acid
EINECS	Contact for details

Quality Control

Our n-Fmoc-R-4-Methoxyphenylglycine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the exacting standards required for sensitive synthetic applications. Certificates of Analysis (COA) detailing identity, purity (typically ≥98%), and specific impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and performance. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.