Description

9-Oxa-2-Azaspiro[5.5]Undecan-9-Carboxylic Acid tert-Butyl Ester is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers specializing in complex heterocyclic chemistry for drug discovery programs targeting central nervous system (CNS) and other therapeutic areas.

Application

• Key Intermediate in Drug Discovery: Serves as a crucial building block for the synthesis of novel spirocyclic compounds with potential pharmacological activity.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities.
• API Synthesis: Employed in the development and scale-up routes for potential Active Pharmaceutical Ingredients (APIs), especially those requiring complex, three-dimensional architectures.
• Proteolysis Targeting Chimera (PROTAC) Development: Its structure makes it a candidate for use as a linker or component in the design of bifunctional PROTAC molecules.
• Chemical Biology Probes: Utilized in the creation of specialized molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A vital material for fine chemical suppliers offering bespoke synthesis services to the pharmaceutical and biotechnology industries.

Basic Information

Product Name	9-Oxa-2-Azaspiro[5.5]Undecan-9-Carboxylic Acid tert-Butyl Ester
CAS No.	1259489-95-6
Molecular Formula	C13H23NO3
Molecular Weight	241.33 g/mol
Synonyms	tert-Butyl 9-oxa-2-azaspiro[5.5]undecane-9-carboxylate; 2-Azaspiro[5.5]undecane-9-carboxylic acid, 9-oxa-, 1,1-dimethylethyl ester; 9-Oxa-2-azaspiro[5.5]undecane-9-carboxylic acid tert-butyl ester; Boc-Protected 9-Oxa-2-Azaspiro[5.5]Undecane; Spirocyclic tert-Butyl Ester Intermediate
EINECS	Contact for details

Quality Control

Our 9-Oxa-2-Azaspiro[5.5]Undecan-9-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our production adheres to cGMP principles where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.