Description

2-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine is a high-value, organoboron building block essential for modern synthetic chemistry. This compound is a key intermediate in the construction of complex molecules, enabling efficient carbon-carbon bond formation via cross-coupling reactions. It is primarily utilized by pharmaceutical and agrochemical research organizations, as well as advanced material scientists, for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery.
• Agrochemical Synthesis: Used to construct pyrimidine-based herbicides, fungicides, and insecticides, leveraging its boronic ester functionality for structural diversification.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as ligands for OLEDs and components for organic semiconductors.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and bioconjugation reagents for target identification and biomarker studies.
• Academic & Contract Research: A versatile reagent for methodological development in organic synthesis and catalysis research within university and CRO laboratories.
• Custom Synthesis & Scale-up: Supplied for process development and pilot-scale manufacturing under cGMP conditions for clinical trial material production.

Basic Information

Product Name	2-Methoxy-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrimidine
CAS No.	1259317-45-7
Molecular Formula	C11H17BN2O3
Molecular Weight	236.08 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-methoxypyrimidine; 2-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 2-Methoxypyrimidine-4-boronic acid pinacol ester; 4-Borono-2-methoxypyrimidine pinacol ester; Pyrimidine, 2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 2-Methoxy-4-pyrimidineboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Every batch of 2-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine is manufactured and tested under a strict quality management system. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards and customer specifications. Certificates of Analysis (COA) with detailed batch-specific data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, store under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended long-term storage temperature is 2-8°C. Allow the sealed container to reach ambient temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.