Description

2,8-Diazaspiro[4.5]Decane-3,8-Dicarboxylic Acid, 8-(1,1-Dimethylethyl) 3-Ethyl Ester, (3R)- is a high-value, chiral spirocyclic building block of significant interest in advanced organic synthesis. This compound matters because it provides a rigid, three-dimensional scaffold that is crucial for modulating the physicochemical and biological properties of complex molecules. It is primarily needed by research and development teams in the pharmaceutical industry for the discovery and development of new therapeutic agents, particularly in areas requiring sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and metabolic disease targets.
• Medicinal Chemistry Research: Used as a privileged scaffold in drug discovery libraries to explore structure-activity relationships (SAR) and improve drug-like properties such as solubility and metabolic stability.
• Asymmetric Synthesis: Employed in the construction of complex, enantiomerically pure molecules due to its defined (3R) stereochemistry.
• Ligand and Catalyst Development: Acts as a backbone for developing novel chiral ligands and organocatalysts used in stereoselective transformations.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and protein function.

Basic Information

Product Name	2,8-Diazaspiro[4.5]Decane-3,8-Dicarboxylic Acid, 8-(1,1-Dimethylethyl) 3-Ethyl Ester, (3R)-
CAS No.	1259039-29-6
Molecular Formula	C15H26N2O4
Molecular Weight	298.38 g/mol
Synonyms	(3R)-8-(tert-Butyl) 3-ethyl 2,8-diazaspiro[4.5]decane-3,8-dicarboxylate; tert-Butyl (3R)-3-ethoxycarbonyl-2,8-diazaspiro[4.5]decane-8-carboxylate; (R)-8-(tert-Butoxycarbonyl)-2,8-diazaspiro[4.5]decane-3-carboxylic Acid Ethyl Ester; (R)-Ethyl 8-(tert-butoxycarbonyl)-2,8-diazaspiro[4.5]decane-3-carboxylate; (3R)-3-Ethoxycarbonyl-2,8-diazaspiro[4.5]decane-8-carboxylic Acid tert-Butyl Ester; BOC-(R)-2,8-Diazaspiro[4.5]decane-3-ethylcarboxylate; (R)-Boc-2,8-Diazaspiro[4.5]decane-3-Carboxylic Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Our 2,8-Diazaspiro[4.5]Decane-3,8-Dicarboxylic Acid, 8-(1,1-Dimethylethyl) 3-Ethyl Ester, (3R)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure it meets the high-purity standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.