Description

4-Bromo-2-Methylphenyl Isocyanide is a versatile and highly reactive organic building block, specifically an aryl isocyanide derivative. This compound is valued for its role as a key ligand and precursor in the synthesis of complex heterocycles and organometallic complexes. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for applications in catalysis and medicinal chemistry.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of novel drug candidates, particularly in multi-component reactions (MCRs) like the Ugi reaction.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where its structural motif can impart specific biological activity.
• Catalyst Ligand Synthesis: Acts as a precursor for creating specialized isocyanide-based ligands used in transition metal catalysis, including palladium-catalyzed cross-coupling reactions.
• Material Science: Employed in the research and development of functional polymers, coordination polymers, and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized in the design of activity-based probes and bio-conjugation reagents due to its specific reactivity profile.
• Academic & Industrial R&D: A fundamental reagent for methodological development in organic synthesis and discovery chemistry within university and corporate laboratories.

Basic Information

Product Name	4-Bromo-2-Methylphenyl Isocyanide
CAS No.	1258794-26-1
Molecular Formula	C8H6BrN
Molecular Weight	196.05 g/mol
Synonyms	2-Methyl-4-bromophenyl isocyanide; 4-Bromo-o-tolyl isocyanide; 1-Bromo-4-isocyano-3-methylbenzene; 2-Methyl-4-bromobenzene isocyanide; 4-Bromo-2-methylbenzenisocyanide; Isocyanic acid, 4-bromo-2-methylphenyl ester; (4-Bromo-2-methylphenyl)isonitrile
EINECS	Contact for details

Quality Control

Our production of 4-Bromo-2-Methylphenyl Isocyanide adheres to stringent internal quality protocols to ensure batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques, including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container tightly sealed under an inert atmosphere to maintain stability, as isocyanides can be sensitive to moisture and oxidation over time.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.