Description

4-(3-Hydroxy-Azetidin-1-Yl)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a sophisticated nitrogen-containing heterocyclic building block of significant interest in advanced organic synthesis. This compound matters as a key intermediate for constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), especially within therapeutic areas targeting the central nervous system and metabolic disorders.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, particularly for neurological and psychiatric applications.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its versatile piperidine-azetidine scaffold.
• Process Chemistry Development: Serves as a key starting material for scaling up the production of target molecules under Good Manufacturing Practice (GMP) conditions.
• Ligand Synthesis: Employed in the creation of complex ligands for catalysis and receptor binding studies.
• Chemical Biology Probes: Utilized to develop tool compounds for investigating biological pathways and target validation.
• Custom Synthesis Projects: A valuable substrate for contract research and manufacturing organizations (CROs/CMOs) specializing in bespoke organic molecules.

Basic Information

Product Name	4-(3-Hydroxy-Azetidin-1-Yl)-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1258640-55-9
Molecular Formula	C13H24N2O3
Molecular Weight	256.34 g/mol
Synonyms	1-Boc-4-(3-hydroxyazetidin-1-yl)piperidine; tert-Butyl 4-(3-hydroxyazetidin-1-yl)piperidine-1-carboxylate; 4-(3-Hydroxyazetidin-1-yl)piperidine-1-carboxylic acid tert-butyl ester; 1-(1-Boc-4-piperidyl)-3-hydroxyazetidine; 1-(1-(tert-Butoxycarbonyl)-4-piperidinyl)-3-hydroxyazetidine; 4-(3-Hydroxy-1-azetidinyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; Piperidine-1-carboxylic acid, 4-(3-hydroxy-1-azetidinyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 4-(3-Hydroxy-Azetidin-1-Yl)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.