Description

tert-Butyl 4-(1,1-Difluoro-2-Hydroxyethyl)Piperidine-1-Carboxylate is a high-value, multi-functional piperidine derivative and a critical advanced pharmaceutical intermediate. This compound matters because it serves as a versatile building block for the synthesis of complex molecules, particularly in medicinal chemistry where its difluoro and hydroxyl motifs are leveraged for bioactivity and metabolic stability. Pharmaceutical R&D and fine chemical synthesis teams need it for developing new active pharmaceutical ingredients (APIs), especially in therapeutic areas targeting the central nervous system and metabolic diseases.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly for CNS and metabolic disorder targets.
• Medicinal Chemistry Building Block: Utilized in structure-activity relationship (SAR) studies and lead optimization due to its difluorinated hydroxyethyl side chain.
• API Synthesis: Serves as a precursor in the multi-step synthesis of complex active pharmaceutical ingredients requiring a functionalized piperidine core.
• Chemical Research: Employed in academic and industrial research for exploring new fluorination chemistry and heterocyclic compound libraries.
• Process Development: Used in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	tert-Butyl 4-(1,1-Difluoro-2-Hydroxyethyl)Piperidine-1-Carboxylate
CAS No.	1258639-21-2
Molecular Formula	C12H21F2NO3
Molecular Weight	265.30 g/mol
Synonyms	1-Boc-4-(1,1-difluoro-2-hydroxyethyl)piperidine; 1-(tert-Butoxycarbonyl)-4-(1,1-difluoro-2-hydroxyethyl)piperidine; 4-(1,1-Difluoro-2-hydroxyethyl)piperidine-1-carboxylic acid tert-butyl ester; tert-Butyl 4-(2-hydroxy-1,1-difluoroethyl)piperidine-1-carboxylate; N-Boc-4-(1,1-difluoro-2-hydroxyethyl)piperidine; 1,1-Difluoro-2-(1-Boc-4-piperidyl)ethanol; BOC-4-(1,1-Difluoro-2-Hydroxyethyl)Piperidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(1,1-Difluoro-2-Hydroxyethyl)Piperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.