Description

3-(2-(Trifluoromethoxy)Phenyl)Pyridin-4-Amine is a high-value, functionalized pyridine derivative that serves as a critical building block in advanced organic synthesis. Its molecular structure, featuring both a pyridin-4-amine core and a trifluoromethoxy-substituted phenyl ring, makes it an essential intermediate for developing novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is particularly sought after by R&D and process chemistry teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in areas like kinase inhibitors, CNS agents, and anti-inflammatory compounds.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the trifluoromethoxy group enhances biological activity and metabolic stability.
• Ligand & Catalyst Development: Serves as a precursor for nitrogen-containing ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as charge-transport layers or emissive materials for OLEDs.
• Chemical Biology Probes: Useful for designing molecular probes and tags to study biological processes and protein interactions.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up manufacturing under cGMP conditions.

Basic Information

Product Name	3-(2-(Trifluoromethoxy)Phenyl)Pyridin-4-Amine
CAS No.	1258634-39-7
Molecular Formula	C12H9F3N2O
Molecular Weight	254.21 g/mol
Synonyms	4-Amino-3-[2-(trifluoromethoxy)phenyl]pyridine; 3-(2-Trifluoromethoxyphenyl)pyridin-4-amine; 4-Pyridinamine, 3-[2-(trifluoromethoxy)phenyl]-; 3-(2-(Trifluoromethoxy)phenyl)-4-aminopyridine; 3-(2-Trifluoromethoxy-phenyl)-pyridin-4-ylamine; 1258634-39-7
EINECS	Contact for details

Quality Control

Every batch of 3-(2-(Trifluoromethoxy)Phenyl)Pyridin-4-Amine is manufactured and tested under strict quality management systems to ensure batch-to-batch consistency and high purity. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing purity, identity, and impurity profiles as confirmed by advanced analytical techniques.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and performance. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.