Description

3-Bromo-5-Fluoro-2-Nitropyridine is a high-purity, multi-functional heterocyclic building block of significant importance in modern synthetic chemistry. Its value lies in the strategic placement of three distinct reactive handles—bromo, fluoro, and nitro groups—on the pyridine scaffold, enabling precise and sequential derivatization. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its halogenated pyridine core.
• Material Science: Serves as a building block for creating functionalized ligands, organic semiconductors, and advanced polymers.
• Cross-Coupling Reactions: The bromo substituent is an excellent site for palladium-catalyzed reactions (e.g., Suzuki, Stille), allowing for carbon-carbon bond formation.
• Nucleophilic Aromatic Substitution: The fluoro and nitro groups activate the pyridine ring for selective displacement reactions with various nucleophiles.
• Chemical Library Synthesis: Employed in medicinal chemistry for the parallel synthesis of diverse compound libraries for high-throughput screening.

Basic Information

Product Name	3-Bromo-5-Fluoro-2-Nitropyridine
CAS No.	1258544-91-0
Molecular Formula	C5H2BrFN2O2
Molecular Weight	220.98 g/mol
Synonyms	2-Nitro-3-bromo-5-fluoropyridine; 5-Fluoro-3-bromo-2-nitropyridine; 3-Bromo-5-fluoro-2-nitropyridine; Pyridine, 3-bromo-5-fluoro-2-nitro-; 1258544-91-0
EINECS	Contact for details

Quality Control

Our 3-Bromo-5-Fluoro-2-Nitropyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment and are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.