Description

(7-Chloro-3-Methyl-4-Oxo-6-((Prop-2-Ynyl(4-(Pyridin-3-Ylmethylcarbamoyl)Phenyl)Amino)Methyl)-3,4-Dihydroquinazolin-2-Yl)Methyl Acetate is a high-purity, synthetically derived quinazolinone derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate or building block for the synthesis of novel bioactive molecules, particularly in the exploration of kinase inhibitors and other targeted therapies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of new chemical entities (NCEs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel small-molecule drug candidates, particularly for oncology and inflammatory diseases.
• Kinase Inhibitor Research: Used as a core scaffold or precursor in the design and development of potent and selective kinase inhibitors.
• Medicinal Chemistry: Serves as a versatile intermediate for structure-activity relationship (SAR) studies and lead optimization programs.
• Biochemical Tool Compound: May be utilized in assay development and target validation studies within academic and industrial research settings.
• Custom Synthesis: Employed by fine chemical suppliers for the contract manufacturing of complex, non-commercialized molecules for client R&D.
• Preclinical Development: Supports the synthesis of compounds required for in vitro and in vivo pharmacological and toxicological evaluations.

Basic Information

Product Name	(7-Chloro-3-Methyl-4-Oxo-6-((Prop-2-Ynyl(4-(Pyridin-3-Ylmethylcarbamoyl)Phenyl)Amino)Methyl)-3,4-Dihydroquinazolin-2-Yl)Methyl Acetate
CAS No.	1258400-23-5
Molecular Formula	C29H26ClN5O4
Molecular Weight	544.00 g/mol
Synonyms	Acetic acid, [(7-chloro-3-methyl-4-oxo-6-[[[4-[[(3-pyridinylmethyl)amino]carbonyl]phenyl](2-propynyl)amino]methyl]-3,4-dihydro-2-quinazolinyl)methyl] ester; 2-Quinazolinemethanol, 7-chloro-3,4-dihydro-3-methyl-4-oxo-6-[[[4-[[(3-pyridinylmethyl)amino]carbonyl]phenyl](2-propynyl)amino]methyl]-, acetate (ester); CAS 1258400-23-5; Quinazolinone derivative intermediate; Kinase inhibitor intermediate; N-(4-(N-(prop-2-yn-1-yl)-4-(pyridin-3-ylmethylcarbamoyl)anilino)methyl)-7-chloro-3-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)methyl acetate
EINECS	Contact for details

Quality Control

Our (7-Chloro-3-Methyl-4-Oxo-6-((Prop-2-Ynyl(4-(Pyridin-3-Ylmethylcarbamoyl)Phenyl)Amino)Methyl)-3,4-Dihydroquinazolin-2-Yl)Methyl Acetate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles, verified by advanced analytical techniques including HPLC, NMR, and MS. We support cGMP compliance for advanced intermediates intended for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.