Description

(1S)- 6,6'-Bis(4-Chlorophenyl)-2,2',3,3'-Tetrahydro-1,1'-Spirobi[1H-Indene]-7,7'-Diol is a high-purity, chiral spirobiindane derivative of significant interest in advanced organic synthesis. This compound matters as a sophisticated building block or chiral ligand for the development of pharmaceuticals and specialty materials, where its precise stereochemistry and functional groups are critical. It is primarily needed by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in asymmetric catalysis and novel drug discovery.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) or metabolic disorder targets.
• Asymmetric Catalysis: Utilized as a chiral ligand or scaffold for constructing metal complexes used in enantioselective synthesis, enhancing the yield and purity of single-isomer products.
• Material Science Research: Acts as a monomer or functional unit in the development of advanced organic polymers and liquid crystals with specific optical or electronic properties.
• Academic & Industrial R&D: Employed in method development and discovery chemistry for studying structure-activity relationships (SAR) and novel reaction pathways.
• Reference Standard: Used as a high-purity analytical standard for quality control and method validation in pharmaceutical and chemical analysis.

Basic Information

Product Name	(1S)- 6,6'-Bis(4-Chlorophenyl)-2,2',3,3'-Tetrahydro-1,1'-Spirobi[1H-Indene]-7,7'-Diol
CAS No.	1258326-99-6
Molecular Formula	C31H24Cl2O2
Molecular Weight	499.43 g/mol
Synonyms	(S)-6,6'-Bis(4-chlorophenyl)-2,2',3,3'-tetrahydro-1,1'-spirobi[indene]-7,7'-diol; (1S)-6,6'-Di(4-chlorophenyl)-2,2',3,3'-tetrahydro-1,1'-spirobi[1H-indene]-7,7'-diol; (S)-Spirobiindane Diol Derivative; 1,1'-Spirobi[indene]-7,7'-diol, 6,6'-bis(4-chlorophenyl)-2,2',3,3'-tetrahydro-, (1S)-; CAS 1258326-99-6
EINECS	Contact for details

Quality Control

Our (1S)- 6,6'-Bis(4-Chlorophenyl)-2,2',3,3'-Tetrahydro-1,1'-Spirobi[1H-Indene]-7,7'-Diol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for research and development applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is easily oxidized; for long-term storage, consider keeping under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.