Description

(1S)-2,2',3,3'-Tetrahydro-6,6'-Diphenyl-1,1'-Spirobi[1H-Indene]-7,7'-Diol CAS NO 1258326-98-5 is a high-purity, chiral spirobiindane derivative, a sophisticated organic building block prized for its unique three-dimensional structure and dual phenolic functionality. This compound is a critical intermediate in advanced organic synthesis, particularly for constructing complex molecules with precise stereochemistry. It is essential for research and development in the pharmaceutical and fine chemical sectors, where it serves as a key precursor for chiral ligands, catalysts, and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral precursor for the synthesis of novel drug candidates, particularly in therapeutic areas requiring high stereochemical purity.
• Asymmetric Catalyst Ligand Synthesis: Used to construct sophisticated chiral ligands for transition metal catalysis, enabling enantioselective reactions in fine chemical manufacturing.
• Advanced Material Research: Serves as a building block for developing novel organic electronic materials or liquid crystals due to its rigid, conjugated spiro structure.
• Chemical Reference Standard: Employed as a high-purity analytical standard for method development and quality control in pharmaceutical analysis.
• Academic & Industrial R&D: Utilized in research laboratories for exploring new synthetic methodologies and studying structure-activity relationships.

Basic Information

Product Name	(1S)-2,2',3,3'-Tetrahydro-6,6'-Diphenyl-1,1'-Spirobi[1H-Indene]-7,7'-Diol
CAS No.	1258326-98-5
Molecular Formula	C31H26O2
Molecular Weight	430.54 g/mol
Synonyms	(S)-6,6'-Diphenyl-2,2',3,3'-tetrahydro-1,1'-spirobi[indene]-7,7'-diol; (1S)-6,6'-Diphenyl-2,2',3,3'-tetrahydro-1,1'-spirobi[1H-indene]-7,7'-diol; (S)-Spirobiindanediol Derivative; (S)-BINOL Hydrogenated Derivative; (1S)-Tetrahydro-Diphenyl-Spirobiindene-Diol; (S)-H8-BINOL Derivative; Chiral Spiro Diol; CAS 1258326-98-5
EINECS	Contact for details

Quality Control

Every batch of (1S)-2,2',3,3'-Tetrahydro-6,6'-Diphenyl-1,1'-Spirobi[1H-Indene]-7,7'-Diol is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including chiral HPLC, NMR, and mass spectrometry, to ensure high chemical and enantiomeric purity suitable for demanding R&D and scale-up applications. Certificates of Analysis (COA) with detailed specifications are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions or an inert atmosphere to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.