Description

(E)-Methyl 4-(4-Cyanophenyl)-2-Oxobut-3-Enoate CAS NO 1257520-11-8 is a high-purity, advanced pharmaceutical intermediate characterized by its α,β-unsaturated ester structure with a cyano-substituted aromatic ring. This compound is critical for the synthesis of complex bioactive molecules, offering a versatile building block for constructing key pharmacophores. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, including kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of targeted drug candidates, particularly in oncology and anti-inflammatory research.
• Kinase Inhibitor Precursor: Serves as a core structural component for the development of protein kinase inhibitors due to its electron-deficient aromatic system.
• Chemical Biology Research: Used in the design and synthesis of molecular probes and activity-based probes for studying enzyme function and signal transduction pathways.
• Agrochemical Synthesis: Employed as an intermediate in the research and development of new active ingredients for crop protection.
• Material Science: Acts as a monomer or cross-linking agent in the research of specialty polymers with specific optical or electronic properties.

Basic Information

Product Name	(E)-Methyl 4-(4-Cyanophenyl)-2-Oxobut-3-Enoate
CAS No.	1257520-11-8
Molecular Formula	C12H9NO3
Molecular Weight	215.20 g/mol
Synonyms	Methyl (2E)-4-(4-cyanophenyl)-2-oxobut-3-enoate; (E)-Methyl 4-(4-cyanophenyl)-2-oxobut-3-enoate; Methyl (E)-4-(4-cyanophenyl)-2-oxobut-3-enoate; 2-Butenoic acid, 4-(4-cyanophenyl)-2-oxo-, methyl ester, (2E)-; 4-(4-Cyanophenyl)-2-oxobut-3-enoic acid methyl ester; CAS 1257520-11-8
EINECS	Contact for details

Quality Control

Our (E)-Methyl 4-(4-Cyanophenyl)-2-Oxobut-3-Enoate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.