Description

(S)-2-Nitro-6-((6-(4-(Trifluoromethoxy)Phenyl)Pyridin-3-Yl)Methoxy)-6,7-Dihydro-5H-Imidazo[2,1-B][1,3]Oxazine is a high-purity, advanced pharmaceutical intermediate featuring a complex, chiral molecular architecture. This compound is of significant value for research and development in medicinal chemistry, particularly in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily targeted at pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing next-generation therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes due to its unique imidazoxazine core and trifluoromethoxy substituent.
• Process Chemistry Development: Serves as a critical chiral precursor for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Biochemical Tool Compound: Potential use in biochemical assays and as a probe for investigating specific biological pathways and enzyme inhibition.
• Custom Synthesis: A starting material for the contract manufacturing of specialized, high-value fine chemicals and custom APIs.

Basic Information

Product Name	(S)-2-Nitro-6-((6-(4-(Trifluoromethoxy)Phenyl)Pyridin-3-Yl)Methoxy)-6,7-Dihydro-5H-Imidazo[2,1-B][1,3]Oxazine
CAS No.	1257426-19-9
Molecular Formula	C22H17F3N4O5
Molecular Weight	474.39 g/mol
Synonyms	(S)-2-Nitro-6-((6-(4-(trifluoromethoxy)phenyl)pyridin-3-yl)methoxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine; 5H-Imidazo[2,1-b][1,3]oxazine, 6,7-dihydro-2-nitro-6-[[6-[4-(trifluoromethoxy)phenyl]-3-pyridinyl]methoxy]-, (6S)-; (6S)-2-Nitro-6-({6-[4-(trifluoromethoxy)phenyl]pyridin-3-yl}methoxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine; CAS 1257426-19-9
EINECS	Contact for details

Quality Control

Our (S)-2-Nitro-6-((6-(4-(Trifluoromethoxy)Phenyl)Pyridin-3-Yl)Methoxy)-6,7-Dihydro-5H-Imidazo[2,1-B][1,3]Oxazine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. Our quality system is designed to meet the stringent requirements of pharmaceutical R&D and cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.