Description

15-Azido-4,7,10,13-Tetraoxapentadecanoic Acid is a specialized bifunctional PEG derivative featuring a carboxylic acid group and a terminal azide moiety. This compound is a critical building block in bioconjugation and click chemistry, enabling the efficient, site-specific labeling and crosslinking of biomolecules and polymers. It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and advanced materials science who require reliable, high-purity linkers for creating novel drug conjugates, diagnostic probes, and functionalized surfaces.

Application

• Bioconjugation and Click Chemistry: Acts as a heterobifunctional crosslinker for coupling carboxylic acid-containing molecules (via the azide group) or amine-containing molecules (via the activated acid) using copper-catalyzed azide-alkyne cycloaddition (CuAAC) or strain-promoted reactions.
• PEGylation Reagent: Used to introduce a polyethylene glycol (PEG) spacer with a reactive azide handle onto peptides, proteins, or small molecule drugs to improve solubility, stability, and pharmacokinetics.
• Polymer and Materials Functionalization: Serves as a monomer or modifier for synthesizing functional polymers (e.g., polyesters, hydrogels) with "clickable" azide groups for subsequent decoration with targeting ligands, dyes, or other payloads.
• Diagnostic Probe Synthesis: Facilitates the construction of imaging agents and biosensors by linking reporter molecules (e.g., fluorophores, chelators) to biological targeting vectors.
• Surface Modification: Used to create azide-functionalized surfaces on chips, nanoparticles, or beads for immobilizing alkyne-tagged biomolecules in microarray and assay development.
• Antibody-Drug Conjugate (ADC) Research: Provides a versatile linker platform for constructing next-generation ADCs with controlled drug-to-antibody ratios (DAR) via site-specific conjugation strategies.

Basic Information

Item	Detail
Product Name	15-Azido-4,7,10,13-Tetraoxapentadecanoic Acid
CAS No.	1257063-35-6
Molecular Formula	C11H19N3O7
Molecular Weight	305.29 g/mol
Synonyms	Azido-PEG4-acid; 15-Azido-4,7,10,13-tetraoxapentadecanoic acid; N3-PEG4-COOH; Azido-PEG4-acetic acid; 2-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethoxy]acetic acid; 11-Aza-4,7,10,13-tetraoxapentadecan-15-oic acid; Azido tetraethylene glycol acetic acid; PEG4-azide-acid
EINECS	Contact for details

Quality Control

Our 15-Azido-4,7,10,13-Tetraoxapentadecanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and FT-IR for functional group verification, to ensure it meets the high standards required for sensitive research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and degradation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.