Description

4-Bromo-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound matters because its unique molecular scaffold, featuring both bromo and trifluoromethyl substituents, enables precise structural modifications critical for developing novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating new molecules with targeted properties. The compound is supplied with stringent quality control to ensure batch-to-batch consistency for your critical synthetic pathways.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of kinase inhibitors and other small-molecule drug candidates targeting various therapeutic areas.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science: Acts as a building block for creating specialized organic electronic materials, such as those used in OLEDs or conductive polymers.
• Chemical Biology: Employed in the design and synthesis of molecular probes and tags for studying biological processes and target engagement.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form complex biaryl structures.
• Functional Group Transformation: The reactive sites allow for further derivatization, enabling the introduction of diverse functional groups to fine-tune molecular properties.

Basic Information

Item	Detail
Product Name	4-Bromo-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine
CAS No.	1256824-06-2
Molecular Formula	C8H4BrF3N2
Molecular Weight	265.03 g/mol
Synonyms	4-Bromo-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine; 4-Bromo-3-(trifluoromethyl)-7-azaindole; 4-Bromo-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 4-bromo-3-(trifluoromethyl)-; 4-Bromo-3-trifluoromethyl-1H-pyrrolo[2,3-b]pyridine; 4-Bromo-3-trifluoromethyl-7-azaindole
EINECS	Contact for details

Quality Control

Our 4-Bromo-3-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and conformity to specifications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment. We are committed to supplying material that meets the high standards required for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is between 2°C and 8°C for long-term stability, as the compound is both light-sensitive and hygroscopic. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.