Description

6-Bromo-5-Chloropyridine-2-Carbonitrile is a high-value halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it an essential intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents, including herbicides and fungicides.
• Material Science Precursor: Employed in the synthesis of functionalized ligands for metal-organic frameworks (MOFs) and other specialty polymers.
• Chemical Biology Probe Development: Serves as a versatile scaffold for creating molecular probes and diagnostic tools.
• Cross-Coupling Reactions: Acts as a substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Nucleophilic Substitution: The bromo and chloro substituents provide distinct sites for selective functionalization via nucleophilic aromatic substitution.

Basic Information

Product Name	6-Bromo-5-Chloropyridine-2-Carbonitrile
CAS No.	1256823-45-6
Molecular Formula	C6H2BrClN2
Molecular Weight	217.45 g/mol
Synonyms	5-Chloro-6-bromopicolinonitrile; 2-Cyano-5-chloro-6-bromopyridine; 6-Bromo-5-chloro-2-cyanopyridine; 5-Chloro-6-bromo-2-pyridinecarbonitrile; 2-Pyridinecarbonitrile, 6-bromo-5-chloro-; Picolinonitrile, 5-chloro-6-bromo-; (6-Bromo-5-chloropyridin-2-yl)carbonitrile
EINECS	Contact for details

Quality Control

Every batch of 6-Bromo-5-Chloropyridine-2-Carbonitrile is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting our clients' regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials and sources of ignition. Due to its light-sensitive nature, handling should be performed under appropriate conditions to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area%)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.