Description

Methyl 2-Ethynylisonicotinate is a specialized organic building block featuring both an ethynyl group and an ester functionality on a pyridine ring. This unique bifunctional structure makes it a valuable intermediate for the synthesis of complex molecules, particularly in pharmaceutical research and advanced material science. It is primarily sought by R&D chemists and process development scientists working in medicinal chemistry, agrochemicals, and the development of functional polymers or ligands for catalysis.

Application

• Pharmaceutical Intermediate: A key synthon for constructing drug candidates, especially those containing substituted pyridine or acetylene moieties, targeting various therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, where the pyridine core is a common structural motif.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers, conductive materials, or metal-organic frameworks (MOFs).
• Ligand and Catalyst Development: The ethynyl and ester groups provide handles for further functionalization to create novel ligands for transition metal catalysis.
• Chemical Biology Probes: Utilized in synthesizing tagged molecules or probes for studying biological processes via click chemistry or other bioorthogonal reactions.
• Academic and Industrial R&D: A versatile building block for exploratory synthetic chemistry in both university laboratories and corporate R&D centers.

Basic Information

Product Name	Methyl 2-Ethynylisonicotinate
CAS No.	1256810-92-0
Molecular Formula	C9H7NO2
Molecular Weight	161.16 g/mol
Synonyms	2-Ethynylisonicotinic acid methyl ester; Methyl 2-ethynylpyridine-4-carboxylate; 4-Pyridinecarboxylic acid, 2-ethynyl-, methyl ester; Isonicotinic acid, 2-ethynyl-, methyl ester; 2-Ethynyl-4-(methoxycarbonyl)pyridine
EINECS	Contact for details

Quality Control

Our Methyl 2-Ethynylisonicotinate is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with customer specifications and internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flames. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.