Description

1-[4-(Trifluoromethyl)Pyridin-2-Yl]Piperidine-4-Carboxylic Acid is a high-value, multi-functional heterocyclic building block featuring a piperidine core substituted with a carboxylic acid group and a trifluoromethylpyridine moiety. This compound is critical for medicinal chemistry research and development, offering a unique scaffold for modulating the physicochemical and pharmacokinetic properties of novel drug candidates. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of small molecule therapeutics, particularly in areas targeting central nervous system (CNS) disorders and metabolic diseases.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), especially for CNS-targeting drugs.
• Medicinal Chemistry Scaffold: Used in structure-activity relationship (SAR) studies and hit-to-lead optimization due to its privileged piperidine structure and trifluoromethyl group.
• Protease Inhibitor Synthesis: Serves as a building block for inhibitors targeting various proteases, where the carboxylic acid group can be derivatized.
• Ligand for Receptor Targeting: Employed in the development of ligands for G-protein-coupled receptors (GPCRs) and other biological targets.
• Agrochemical Research: Potential intermediate in the discovery of new herbicides or fungicides, leveraging the biological activity of the trifluoromethylpyridine group.
• Material Science Precursor: Can be used to synthesize functionalized polymers or metal-organic frameworks (MOFs) for specialized applications.

Basic Information

Product Name	1-[4-(Trifluoromethyl)Pyridin-2-Yl]Piperidine-4-Carboxylic Acid
CAS No.	1256792-04-7
Molecular Formula	C12H13F3N2O2
Molecular Weight	274.24 g/mol
Synonyms	1-[4-(Trifluoromethyl)pyridin-2-yl]piperidine-4-carboxylic acid; 4-Piperidinecarboxylic acid, 1-[4-(trifluoromethyl)-2-pyridinyl]-; 1-(4-(Trifluoromethyl)pyridin-2-yl)piperidine-4-carboxylic acid; 2-(4-Carboxypiperidin-1-yl)-4-(trifluoromethyl)pyridine; Piperidine-4-carboxylic acid, 1-[4-(trifluoromethyl)-2-pyridinyl]-; 1256792-04-7
EINECS	Contact for details

Quality Control

Our 1-[4-(Trifluoromethyl)Pyridin-2-Yl]Piperidine-4-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP guidelines for advanced pharmaceutical intermediates, ensuring reliability for your most sensitive R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.