Description

6-(Difluoromethyl)Pyridin-3-Ol CAS NO 1256791-37-3 is a high-value pyridine derivative characterized by a difluoromethyl substituent, a structural motif that significantly influences its physicochemical and biological properties. This compound is a critical advanced pharmaceutical intermediate and a versatile building block in modern synthetic chemistry, enabling the development of novel active ingredients. It is primarily sought after by R&D and production teams in the pharmaceutical and agrochemical industries for the synthesis of new drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Serves as a crucial building block for the research and production of next-generation herbicides, fungicides, and insecticides, leveraging the fluorine atom's ability to enhance bioavailability and metabolic stability.
• Organic Synthesis Reagent: Used as a versatile fluorinated precursor in cross-coupling reactions, nucleophilic substitutions, and other transformations to introduce the difluoromethylpyridyl moiety into complex molecules.
• Material Science Research: Employed in the development of novel fluorinated organic materials, including liquid crystals, polymers, and electronic chemicals, where the difluoromethyl group can modify electronic properties.
• Chemical Biology & Proteomics: Acts as a probe or a tag in chemical biology research due to the unique reactivity and spectroscopic signature of the fluorine atoms.

Basic Information

Item	Details
Product Name	6-(Difluoromethyl)Pyridin-3-Ol
CAS No.	1256791-37-3
Molecular Formula	C6H5F2NO
Molecular Weight	145.11 g/mol
Synonyms	3-Hydroxy-6-(difluoromethyl)pyridine; 6-(Difluoromethyl)-3-hydroxypyridine; 6-(Difluoromethyl)-3-pyridinol; 5-Hydroxy-2-(difluoromethyl)pyridine; 2-(Difluoromethyl)-5-hydroxypyridine; 3-Pyridinol, 6-(difluoromethyl)-; 6-Difluoromethyl-pyridin-3-ol
EINECS	Contact for details

Quality Control

Our 6-(Difluoromethyl)Pyridin-3-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage, consider an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.