Description

6-Bromo-5-Chloronicotinonitrile is a high-purity, multi-functional halogenated pyridine derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its value lies in its unique halogen substitution pattern, which enables precise molecular construction for complex target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging its halogenated pyridine core.
• Material Science Research: Serves as a precursor for functionalized ligands and organic electronic materials due to its electron-withdrawing nitrile group.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions, facilitating carbon-carbon and carbon-heteroatom bond formation.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and protein interactions.

Basic Information

Product Name	6-Bromo-5-Chloronicotinonitrile
CAS No.	1256790-78-9
Molecular Formula	C6H2BrClN2
Molecular Weight	217.45 g/mol
Synonyms	5-Chloro-6-bromonicotinonitrile; 3-Cyano-5-chloro-6-bromopyridine; 6-Bromo-5-chloro-3-pyridinecarbonitrile; 6-Bromo-5-chloropyridine-3-carbonitrile; 5-Chloro-6-bromo-3-cyanopyridine; Nicotinonitrile, 6-bromo-5-chloro-; (5-Chloro-6-bromopyridin-3-yl)carbonitrile
EINECS	Contact for details

Quality Control

Our 6-Bromo-5-Chloronicotinonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.