Description

Ethyl 2-Bromo-4-Chloronicotinate is a high-purity, multi-functional halogenated nicotinate ester building block essential for advanced organic synthesis. This compound is valued for its reactivity, particularly in cross-coupling reactions and as a precursor for complex heterocyclic systems. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly kinase inhibitors and other nitrogen-containing heterocycles.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with tailored biological activity.
• Material Science: Serves as a precursor for functionalized ligands and monomers used in specialty polymers and coordination chemistry.
• Cross-Coupling Reactions: An effective substrate for Suzuki, Stille, and Negishi couplings due to the reactive bromo and chloro substituents.
• Academic & Contract Research: Employed in method development and discovery chemistry within university and CRO laboratories.
• Fine Chemical Synthesis: Building block for the preparation of complex, multi-substituted pyridine derivatives.

Basic Information

Product Name	Ethyl 2-Bromo-4-Chloronicotinate
CAS No.	1256561-52-0
Molecular Formula	C8H7BrClNO2
Molecular Weight	264.50 g/mol
Synonyms	2-Bromo-4-chloronicotinic acid ethyl ester; Ethyl 2-bromo-4-chloropyridine-3-carboxylate; 3-Pyridinecarboxylic acid, 2-bromo-4-chloro-, ethyl ester; 4-Chloro-2-bromonicotinic acid ethyl ester; 2-Bromo-4-chloro-3-pyridinecarboxylic acid ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 2-Bromo-4-Chloronicotinate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC, GC, NMR, and mass spectrometry to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.