Description

3,5-Difluoro-4-Methoxybenzoic Acid Ethyl Ester is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. Its core value lies in the strategic placement of fluorine atoms and the methoxy group, which are critical for modulating the electronic properties, lipophilicity, and metabolic stability of target molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for constructing fluorinated drug candidates, particularly in oncology, CNS, and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides where fluorine substitution enhances bioactivity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor for fluorinated mesogens in electronic display technologies due to its aromatic core and ester functionality.
• Organic Electronics: Employed in the synthesis of monomers and polymers for organic light-emitting diodes (OLEDs) and semiconductors.
• Chemical Research: A versatile reagent for Suzuki-Miyaura and other cross-coupling reactions to create complex, diversely functionalized biaryl systems.
• Fluorine Chemistry Studies: Used as a model compound to study the effects of fluorine substitution patterns on aromatic reactivity and physical properties.

Basic Information

Product Name	3,5-Difluoro-4-Methoxybenzoic Acid Ethyl Ester
CAS No.	1256482-44-6
Molecular Formula	C10H10F2O3
Molecular Weight	216.18 g/mol
Synonyms	Ethyl 3,5-Difluoro-4-methoxybenzoate; Benzoic acid, 3,5-difluoro-4-methoxy-, ethyl ester; 4-Methoxy-3,5-difluorobenzoic acid ethyl ester; 3,5-Difluoro-4-methoxy-benzoic acid ethyl ester; Ethyl 4-methoxy-3,5-difluorobenzoate
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-4-Methoxybenzoic Acid Ethyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliable supply for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and heat sources. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.