Description

6-Bromo-1-(T-Butyldimethylsilanyl)Indole-3-Boronic Acid Pinacol Ester is a high-value, protected indole boronic ester derivative, serving as a critical synthetic intermediate in advanced organic synthesis. Its core value lies in enabling precise cross-coupling reactions, such as Suzuki-Miyaura couplings, to construct complex heterocyclic scaffolds with high efficiency and selectivity. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex indole-based drug candidates, including kinase inhibitors and receptor modulators.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides with indole core structures.
• Material Science Research: Employed in the creation of organic electronic materials, such as OLEDs and semiconductors, where precise molecular architecture is required.
• Suzuki-Miyaura Cross-Coupling Reactions: Acts as a versatile boronic ester partner for palladium-catalyzed C-C bond formation with various aryl/heteroaryl halides.
• Medicinal Chemistry & SAR Studies: Facilitates the rapid exploration of structure-activity relationships by allowing efficient introduction of the 6-bromoindole moiety into diverse molecular frameworks.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting outsourced drug discovery and custom synthesis projects.

Basic Information

Product Name	6-Bromo-1-(T-Butyldimethylsilanyl)Indole-3-Boronic Acid Pinacol Ester
CAS No.	1256358-99-2
Molecular Formula	C20H31BBrNO2Si
Molecular Weight	436.27 g/mol
Synonyms	6-Bromo-1-[(1,1-dimethylethyl)dimethylsilyl]-1H-indole-3-boronic acid, pinacol ester; 6-Bromo-1-(tert-butyldimethylsilyl)-1H-indole-3-boronic acid pinacol ester; 6-Bromo-1-TBDMS-indole-3-boronic acid pinacol ester; 1-(tert-Butyldimethylsilyl)-6-bromoindole-3-boronic acid pinacol ester; 6-Bromo-1-[(tert-butyldimethylsilyl)]indole-3-boronic acid pinacol ester; Pinacol 6-bromo-1-(tert-butyldimethylsilyl)-1H-indole-3-boronate; B-{6-Bromo-1-[(1,1-dimethylethyl)dimethylsilyl]-1H-indol-3-yl}-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 6-Bromo-1-(T-Butyldimethylsilanyl)Indole-3-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, assay, and impurity profiles. Our quality commitment supports compliance with cGMP guidelines for advanced pharmaceutical intermediates, ensuring reliability for your critical research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Assay (NMR)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.