Description

2-(Dimethylamino)Pyridine-5-Boronic Acid, Hydrate is a versatile and highly valuable bifunctional organoboron building block, essential for modern synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, while its pyridine scaffold offers additional coordination and functionalization sites. This compound is critically needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), especially in kinase inhibitor and other small-molecule drug discovery programs.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides requiring specific heterocyclic frameworks.
• Material Science & OLED Development: Serves as a precursor for creating advanced organic electronic materials, including ligands for metal-organic frameworks (MOFs) and emissive layers in organic light-emitting diodes (OLEDs).
• Ligand & Catalyst Design: The dimethylamino-pyridine moiety can act as a ligand for metal catalysts or be incorporated into more complex catalytic systems.
• Chemical Biology & Bioconjugation: Useful for modifying biomolecules or creating chemical probes due to its orthogonal reactivity.
• Polymer Chemistry: Employed in the synthesis of functionalized polymers and dendrimers with tailored properties.

Basic Information

Item	Detail
Product Name	2-(Dimethylamino)Pyridine-5-Boronic Acid, Hydrate
CAS No.	1256355-24-4
Molecular Formula	C7H11BN2O2 • xH2O
Molecular Weight	165.99 (Anhydrous basis)
Synonyms	5-(Dimethylamino)-2-pyridineboronic acid hydrate; (5-(Dimethylamino)pyridin-2-yl)boronic acid hydrate; 2-Pyridineboronic acid, 5-(dimethylamino)-, hydrate; DMAP-5-Boronic Acid Hydrate; 2-Dimethylaminopyridine-5-boronic acid pinacol ester (related compound); 5-(N,N-Dimethylamino)pyridine-2-boronic acid
EINECS	Contact for details

Quality Control

Every batch of 2-(Dimethylamino)Pyridine-5-Boronic Acid, Hydrate undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive cross-coupling reactions. Our quality assurance protocols are designed to guarantee batch-to-batch consistency and reliability. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥95.0% (Anhydrous basis)
Purity (HPLC, Area%)	≥97.0%
Water Content (KF)	≤10.0% (Hydrate form)
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.