Description

3-Chloro-4-Pyridineboronic Acid Hydrate is a versatile and high-value boronic acid derivative, serving as a critical building block in modern synthetic chemistry. Its primary value lies in enabling the formation of carbon-carbon bonds via the Suzuki-Miyaura cross-coupling reaction, a cornerstone methodology for constructing complex molecules. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise functionalization of pyridine-based scaffolds.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing functionalized pyridine rings.
• Agrochemical Synthesis: Used to create novel herbicides, fungicides, and insecticides with tailored biological activity.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for transition metal catalysis and organocatalysts.
• Material Science Research: Building block for constructing organic electronic materials, metal-organic frameworks (MOFs), and functional polymers.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological systems and enzyme inhibition.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke chemical synthesis projects.

Basic Information

Product Name	3-Chloro-4-Pyridineboronic Acid Hydrate
CAS No.	1256355-22-2
Molecular Formula	C5H5BClNO2 • xH2O
Molecular Weight	157.36 (Anhydrous basis)
Synonyms	(3-Chloro-4-pyridinyl)boronic acid hydrate; 3-Chloro-4-pyridylboronic acid hydrate; 4-Borono-3-chloropyridine hydrate; 3-Chloro-4-pyridineboronic acid; (3-Chloro-pyridin-4-yl)-boronic acid; 3-Chloro-4-pyridinylboronic acid; Boronic acid, B-(3-chloro-4-pyridinyl)-, hydrate
EINECS	Contact for details

Quality Control

Our 3-Chloro-4-Pyridineboronic Acid Hydrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and assay, NMR for structural confirmation, and KF titration for water content. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 3.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.