Description

2-(Isobutylthio)-5-(Trifluoromethyl)Pyridine-3-Boronic Acid is a high-value, multi-functional organoboron building block essential for modern synthetic chemistry. Its core value lies in enabling efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone for constructing complex molecular architectures. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing active pharmaceutical ingredients (APIs), particularly those containing the trifluoromethylpyridine moiety, which is prized for its metabolic stability and lipophilicity.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the pyridine-boronic acid structure facilitates the creation of novel compounds with enhanced efficacy.
• Material Science Research: Serves as a precursor for developing organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed Suzuki-Miyaura cross-coupling to introduce the 2-(isobutylthio)-5-(trifluoromethyl)pyridin-3-yl group into target molecules.
• Chemical Biology & Medicinal Chemistry: Utilized in fragment-based drug discovery and the synthesis of chemical probes for studying biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.

Basic Information

Product Name	2-(Isobutylthio)-5-(Trifluoromethyl)Pyridine-3-Boronic Acid
CAS No.	1256345-54-6
Molecular Formula	C11H15BF3NO2S
Molecular Weight	289.11 g/mol
Synonyms	[2-(2-Methylpropylsulfanyl)-5-(trifluoromethyl)pyridin-3-yl]boronic acid; 2-(Isobutylthio)-5-(trifluoromethyl)-3-pyridineboronic acid; 5-(Trifluoromethyl)-2-(isobutylthio)pyridine-3-boronic acid; 3-Borono-2-(isobutylthio)-5-(trifluoromethyl)pyridine; Boronic acid, B-[2-[(2-methylpropyl)thio]-5-(trifluoromethyl)-3-pyridinyl]-; 2-(Isobutylsulfanyl)-5-(trifluoromethyl)pyridine-3-boronic acid
EINECS	Contact for details

Quality Control

Our 2-(Isobutylthio)-5-(Trifluoromethyl)Pyridine-3-Boronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.