Description

(1S,2R,3R,4R)-3-(Methoxycarbonyl)Spiro[Bicyclo[2.2.1]Heptane-7,1'-Cyclopropane]-2-Carboxylicacid is a high-purity, stereochemically defined advanced pharmaceutical intermediate (API) characterized by its complex spirocyclic and bicyclic architecture. This compound matters as a critical chiral building block for the synthesis of novel, high-value therapeutic agents, offering precise control over molecular geometry essential for biological activity. It is primarily needed by research and development teams in the pharmaceutical and biotechnology sectors for creating next-generation small molecule drugs targeting complex diseases.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs) for clinical development.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for novel drug candidates.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Asymmetric Synthesis: Utilized as a starting material or intermediate in catalytic asymmetric reactions to construct complex molecular frameworks.
• Protease Inhibitor Development: Potential building block for inhibitors targeting specific enzymes, given its constrained, polycyclic carboxylic acid structure.
• Chemical Biology Probes: Can be incorporated into molecular probes for studying biological pathways and target engagement.

Basic Information

Item	Detail
Product Name	(1S,2R,3R,4R)-3-(Methoxycarbonyl)Spiro[Bicyclo[2.2.1]Heptane-7,1'-Cyclopropane]-2-Carboxylicacid
CAS No.	1256276-95-5
Molecular Formula	C13H16O4
Molecular Weight	236.26 g/mol
Synonyms	(1S,2R,3R,4R)-3-(Methoxycarbonyl)-7-spirocyclopropanebicyclo[2.2.1]heptane-2-carboxylic acid; (1S,2R,3R,4R)-3-(Carbomethoxy)-7-spirocyclopropanebicyclo[2.2.1]heptane-2-carboxylic acid; Spiro[bicyclo[2.2.1]heptane-7,1'-cyclopropane]-2-carboxylic acid, 3-(methoxycarbonyl)-, (1S,2R,3R,4R)-; 1256276-95-5; (1S,2R,3R,4R)-3-Methoxycarbonyl-7-spirocyclopropanebicyclo[2.2.1]heptane-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our (1S,2R,3R,4R)-3-(Methoxycarbonyl)Spiro[Bicyclo[2.2.1]Heptane-7,1'-Cyclopropane]-2-Carboxylicacid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and stereochemical purity suitable for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. The compound may be moisture-sensitive; keep the original container tightly sealed under inert atmosphere for long-term storage.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.