Description

1-tert-Butyl 3-Methyl 5,5-Difluoropiperidine-1,3-Dicarboxylate is a high-purity, advanced pharmaceutical intermediate featuring a difluorinated piperidine scaffold. This compound is critical for medicinal chemistry research and development, enabling the synthesis of novel bioactive molecules with enhanced metabolic stability and membrane permeability. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of new drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) and antiviral drugs.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to introduce fluorine atoms, which can improve a compound's potency, selectivity, and pharmacokinetic profile.
• Agrochemical Synthesis: Serves as a precursor in the development of novel herbicides and pesticides, where the difluoropiperidine moiety can contribute to biological activity.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Process Chemistry & Scale-Up: Used in the development and optimization of scalable synthetic routes for commercial manufacturing.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects and contract research organizations (CROs/CMOs) serving the life sciences sector.

Basic Information

Product Name	1-tert-Butyl 3-Methyl 5,5-Difluoropiperidine-1,3-Dicarboxylate
CAS No.	1255667-06-1
Molecular Formula	C13H21F2NO4
Molecular Weight	293.31 g/mol
Synonyms	5,5-Difluoropiperidine-1,3-dicarboxylic acid 1-tert-butyl 3-methyl ester; tert-Butyl methyl 5,5-difluoropiperidine-1,3-dicarboxylate; 1-(tert-Butoxycarbonyl)-3-(methoxycarbonyl)-5,5-difluoropiperidine; 1-Boc-3-methyl 5,5-difluoropiperidine-1,3-dicarboxylate; 5,5-Difluoro-1,3-piperidinedicarboxylic acid 1-(1,1-dimethylethyl) 3-methyl ester; 5,5-Difluoropiperidine-1,3-dicarboxylic acid tert-butyl methyl ester
EINECS	Contact for details

Quality Control

Our 1-tert-Butyl 3-Methyl 5,5-Difluoropiperidine-1,3-Dicarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.