Description

5-Bromo-7-Fluoroisobenzofuran-1(3H)-One is a high-purity, advanced pharmaceutical intermediate characterized by its halogenated isobenzofuranone structure. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs) and novel chemical entities, offering a versatile building block for medicinal chemistry research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific bromine and fluorine substituents into target molecules.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of new drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the creation of novel herbicides and pesticides, where the halogen atoms contribute to biological activity and metabolic stability.
• Material Science Research: Acts as a precursor for the development of specialty polymers and organic electronic materials due to its fused ring system.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization to explore new chemical space.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and scale-up services for client projects.
• Academic Research: Used in university and institutional labs for fundamental studies in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	5-Bromo-7-Fluoroisobenzofuran-1(3H)-One
CAS No.	1255208-34-4
Molecular Formula	C8H4BrFO2
Molecular Weight	231.02 g/mol
Synonyms	5-Bromo-7-fluorophthalide; 5-Bromo-7-fluoro-1(3H)-isobenzofuranone; 7-Fluoro-5-bromophthalide; 3H-Isobenzofuran-1-one, 5-bromo-7-fluoro-; 5-Bromo-7-fluoro-3H-isobenzofuran-1-one
EINECS	Contact for details

Quality Control

Our 5-Bromo-7-Fluoroisobenzofuran-1(3H)-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications. Our quality commitment supports applications requiring high-purity intermediates for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container must be kept tightly closed to prevent contamination and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.