Description

8-Chloro-3-(cyclopropylmethyl)-7-iodo-[1,2,4]triazolo[4,3-a]pyridine is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 1254981-17-3. This compound is a critical building block in modern medicinal chemistry, valued for its unique heterocyclic structure that enables the synthesis of novel bioactive molecules. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly within oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs) targeting specific biological pathways.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Oncology Drug Development: Employed in the research and synthesis of potential kinase inhibitors and other targeted cancer therapies.
• CNS-Active Compound Synthesis: Serves as a building block for developing compounds intended to interact with central nervous system receptors.
• Chemical Biology Probes: Utilized in the creation of specialized molecular tools for studying enzyme function and cellular processes.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.

Basic Information

Product Name	8-Chloro-3-(cyclopropylmethyl)-7-iodo-[1,2,4]triazolo[4,3-a]pyridine
CAS No.	1254981-17-3
Molecular Formula	C10H9ClIN3
Molecular Weight	333.56 g/mol
Synonyms	8-Chloro-3-(cyclopropylmethyl)-7-iodo-1,2,4-triazolo[4,3-a]pyridine; 7-Iodo-8-chloro-3-(cyclopropylmethyl)-[1,2,4]triazolo[4,3-a]pyridine; 1254981-17-3; Triazolopyridine derivative; CP-Iodo-Triazolopyridine; Advanced Pharma Intermediate 1254981-17-3
EINECS	Contact for details

Quality Control

Our 8-Chloro-3-(cyclopropylmethyl)-7-iodo-[1,2,4]triazolo[4,3-a]pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS), to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.