Description

3-(Cyclopropylmethyl)-7-(4-Phenylpiperidin-1-Yl)-8-(Trifluoromethyl)-[1,2,4]Triazolo[4,3-A]Pyridine is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure incorporating a trifluoromethyl group. This compound is of significant value for its role as a key building block in the research and development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology therapeutic areas. It is primarily required by pharmaceutical R&D laboratories, contract research and manufacturing organizations (CROs/CMOs), and fine chemical suppliers serving the global life sciences industry.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, especially those targeting neurological receptors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its unique triazolopyridine scaffold.
• Preclinical Development: Employed in the scale-up synthesis of compounds for pharmacological profiling and toxicology studies.
• Reference Standard: Utilized as an analytical standard for method development and quality control in API manufacturing.
• Chemical Biology Probes: Acts as a starting material for developing tool compounds to study specific biological pathways.

Basic Information

Product Name	3-(Cyclopropylmethyl)-7-(4-Phenylpiperidin-1-Yl)-8-(Trifluoromethyl)-[1,2,4]Triazolo[4,3-A]Pyridine
CAS No.	1254977-87-1
Molecular Formula	C22H23F3N4
Molecular Weight	400.44 g/mol
Synonyms	8-(Trifluoromethyl)-3-(cyclopropylmethyl)-7-(4-phenyl-1-piperidinyl)-[1,2,4]triazolo[4,3-a]pyridine; 3-Cyclopropylmethyl-7-(4-phenylpiperidin-1-yl)-8-trifluoromethyl-[1,2,4]triazolo[4,3-a]pyridine; [1,2,4]Triazolo[4,3-a]pyridine, 3-(cyclopropylmethyl)-7-(4-phenyl-1-piperidinyl)-8-(trifluoromethyl)-; UNII-9S5P6SJU27; 9S5P6SJU27; BDBM50190035; AKOS025147065; CHEMBL3185222
EINECS	Contact for details

Quality Control

Our 3-(Cyclopropylmethyl)-7-(4-Phenylpiperidin-1-Yl)-8-(Trifluoromethyl)-[1,2,4]Triazolo[4,3-A]Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D. Comprehensive Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize moisture exposure. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.