Description

4-Oxo-2-[4-(Trifluoromethoxy)Phenyl]-1,3,8-Triazaspiro[4.5]Dec-1-Ene, 4-(4-Oxo-1,3,8-Triazaspiro[4.5]Dec-1-En-2-Yl)-Alpha,Alpha,α-Trifluoroanisole is a high-value, complex heterocyclic compound featuring a spirocyclic core and a trifluoromethoxy phenyl group, making it a sophisticated building block for advanced chemical synthesis. Its precise molecular architecture offers significant utility in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where the trifluoromethoxy moiety is prized for enhancing metabolic stability and bioavailability. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to create next-generation products with targeted properties.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, particularly in central nervous system (CNS), oncology, and anti-inflammatory therapeutic areas.
• Agrochemical Research: Serves as a core scaffold for designing novel herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing trifluoromethoxy group.
• Chemical Biology Probe: Used in academic and industrial research to study enzyme inhibition and protein-ligand interactions due to its complex, drug-like structure.
• Material Science Research: Investigated as a potential monomer or additive for creating specialty polymers with unique thermal or optical properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.

Basic Information

Product Name	4-Oxo-2-[4-(Trifluoromethoxy)Phenyl]-1,3,8-Triazaspiro[4.5]Dec-1-Ene, 4-(4-Oxo-1,3,8-Triazaspiro[4.5]Dec-1-En-2-Yl)-Alpha,Alpha,α-Trifluoroanisole
CAS No.	1253924-71-8
Molecular Formula	C19H19F3N4O2
Molecular Weight	392.38 g/mol
Synonyms	2-[4-(Trifluoromethoxy)phenyl]-1,3,8-triazaspiro[4.5]dec-1-en-4-one; 4-(4-Oxo-1,3,8-triazaspiro[4.5]dec-1-en-2-yl)-α,α,α-trifluoroanisole; 1,3,8-Triazaspiro[4.5]dec-1-ene-2,4-dione, 2-[4-(trifluoromethoxy)phenyl]-; CAS 1253924-71-8; Spirocyclic trifluoromethoxy aniline derivative; TFMP-spirotriazinone
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced under strict quality management systems and undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) detailing key parameters such as assay (HPLC), related substances, and residual solvents. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated research and development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed in a dry environment. For long-term storage, consider using inert gas purging.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.