Description

tert-Butyl [1-(Pyridin-3-Ylmethyl)Piperidin-4-Yl]Methylcarbamate CAS NO 1253403-51-8 is a high-purity, advanced pharmaceutical intermediate featuring a piperidine core modified with pyridinylmethyl and tert-butoxycarbonyl (Boc) protecting groups. This compound matters for its critical role in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting neurological and receptor-based pathways. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities and novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel drug candidates, especially in medicinal chemistry programs.
• Neurological Research: Used in the development of compounds targeting central nervous system (CNS) receptors due to its piperidine scaffold.
• Protease Inhibitor Synthesis: Serves as a precursor in the creation of protease inhibitors and other enzyme-targeting molecules.
• Chemical Biology: Employed in the synthesis of tool compounds and probes for studying biological pathways and protein functions.
• Process Development: Utilized in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke molecules for clients.

Basic Information

Product Name	tert-Butyl [1-(Pyridin-3-Ylmethyl)Piperidin-4-Yl]Methylcarbamate
CAS No.	1253403-51-8
Molecular Formula	C18H29N3O2
Molecular Weight	319.45 g/mol
Synonyms	tert-Butyl N-[[1-(3-pyridylmethyl)piperidin-4-yl]methyl]carbamate; 1-(Pyridin-3-ylmethyl)piperidine-4-carboxylic acid, tert-butyl ester (related); Boc-4-(aminomethyl)-1-(3-pyridylmethyl)piperidine; N-Boc-1-(3-Pyridylmethyl)-4-piperidinemethylamine; 1-(3-Pyridinylmethyl)-4-(aminomethyl)piperidine, N-Boc protected; 4-[[(tert-Butoxycarbonyl)amino]methyl]-1-(3-pyridinylmethyl)piperidine; 1253403-51-8; Boc-Pip(3-Pic)-CH2NH2 (abbreviated form)
EINECS	Contact for details

Quality Control

Our tert-Butyl [1-(Pyridin-3-Ylmethyl)Piperidin-4-Yl]Methylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical R&D and process chemistry. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥97% by HPLC), and impurity profiles is provided with every shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which may affect stability and performance. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single unknown impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.