Description

Azido-PEG3-CH2CO2Me is a heterobifunctional polyethylene glycol (PEG) linker featuring a reactive azide group and a methyl ester terminus. This compound is a critical reagent in bioconjugation and materials science, enabling the controlled, site-specific coupling of molecules via click chemistry. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for applications such as drug delivery system development, surface functionalization, and polymer modification.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Development: The azide group participates in copper-catalyzed or strain-promoted azide-alkyne cycloaddition (CuAAC/SPAAC) with alkynes for precise labeling and payload attachment.
• PEGylation and Linker Chemistry: Serves as a versatile spacer arm to improve solubility, reduce immunogenicity, and prolong circulation time of therapeutic peptides, proteins, and oligonucleotides.
• Surface Modification and Functionalization: Used to create bio-inert or reactive coatings on nanoparticles, biosensors, and medical devices.
• Polymer and Dendrimer Synthesis: Acts as a building block for constructing functionalized polymers with tailored properties via click chemistry methodologies.
• Crosslinking Agent: Facilitates the formation of hydrogels and other crosslinked networks for tissue engineering and controlled release applications.
• Proteomics and Chemical Biology: Employed as a tool for labeling and enriching biomolecules for analytical studies.

Basic Information

Product Name	Azido-PEG3-CH2CO2Me
CAS No.	1253389-31-9
Molecular Formula	C11H21N3O5
Molecular Weight	275.30 g/mol
Synonyms	Azido-PEG3-acid methyl ester; Methyl 2,2-dimethyl-4-oxo-3,8,11-trioxa-5-azatetradecan-14-oate; 3-Azidopropyl-PEG2-methyl acetate; 11-Azido-3,6,9-trioxaundecan-1-yl methyl ester; Azido-PEG3-C2-methyl ester; PEG3-azide methyl ester; Azido-tri(ethylene glycol) methyl acetate; N3-PEG3-CH2COOMe
EINECS	Contact for details

Quality Control

Our Azido-PEG3-CH2CO2Me is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your research and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Keep container tightly sealed in a desiccated environment.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.