Description

tert-Butyl 2-Oxo-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Spiro[Indoline-3,4'-Piperidine]-1'-Carboxylate is a high-value, multifunctional building block featuring a spirocyclic indoline core integrated with a protected piperidine nitrogen and a pinacol boronate ester. This compound is specifically engineered for advanced pharmaceutical research and development, serving as a critical intermediate in modern synthetic chemistry. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for constructing complex molecular architectures, particularly in the synthesis of targeted small molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Suzuki-Miyaura Cross-Coupling Reactions: The pinacol boronate ester moiety enables efficient carbon-carbon bond formation, a cornerstone reaction in constructing complex organic molecules.
• Medicinal Chemistry & SAR Studies: Used to explore structure-activity relationships by introducing the spiro[indoline-3,4'-piperidine] scaffold into lead compounds.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a versatile linker or warhead component in the design of bifunctional degraders.
• Chemical Biology Probes: Employed in the development of tool compounds for target identification and validation within biological pathways.
• Process Chemistry & Scale-Up: Provides a stable, crystalline intermediate suitable for optimization and kilogram-scale production under GMP-like conditions.

Basic Information

Product Name	tert-Butyl 2-Oxo-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Spiro[Indoline-3,4'-Piperidine]-1'-Carboxylate
CAS No.	1253288-12-8
Molecular Formula	C23H33BN2O5
Molecular Weight	428.33 g/mol
Synonyms	1'-Boc-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)spiro[indoline-3,4'-piperidin]-2-one; tert-Butyl 2-oxo-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1'H-spiro[indole-3,4'-piperidine]-1'-carboxylate; 5-BPin-spiro[indoline-3,4'-piperidine]-1'-carboxylic acid tert-butyl ester; 1'-Boc-5-BPin-spiro[indoline-3,4'-piperidine]-2-one; Spiro[Indoline-3,4'-Piperidine]-1'-Carboxylic Acid, 2-Oxo-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-, 1,1-Dimethylethyl Ester; BOC-Spiro[Indoline-3,4'-Piperidine]-BPin Intermediate
EINECS	Contact for details

Quality Control

Every batch of tert-Butyl 2-Oxo-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Spiro[Indoline-3,4'-Piperidine]-1'-Carboxylate is manufactured and tested under a strict quality management system. We provide comprehensive analytical data including HPLC purity, NMR (1H & 13C) for structural confirmation, and mass spectrometry to ensure identity and potency. Certificates of Analysis (COA) detailing all specifications are available for each lot and can be tailored to meet specific client requirements for advanced research or cGMP starting material applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when possible to maintain stability and purity. Keep container tightly sealed in a desiccated environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.