Description

cis-6-Methyl-Piperidine-1,3-Dicarboxylic Acid 1-tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and protected functional groups. This compound matters as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), enabling precise molecular construction for targeted therapies. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries working on novel drug candidates, particularly in areas requiring chiral piperidine scaffolds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of potential drug candidates targeting the central nervous system (CNS), metabolic disorders, and infectious diseases.
• Protease Inhibitor Research: Serves as a core structural component in the development of novel protease inhibitors, including those for viral targets.
• Chemical Biology & Medicinal Chemistry: Used in library synthesis for high-throughput screening and structure-activity relationship (SAR) studies to optimize lead compounds.
• Peptidomimetic Development: Employed to create conformationally constrained peptide analogs, enhancing metabolic stability and bioavailability.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or starting material in enantioselective catalytic processes to introduce stereogenic centers.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations (CROs/CMOs) for cGMP production of clinical trial materials.

Basic Information

Product Name	cis-6-Methyl-Piperidine-1,3-Dicarboxylic Acid 1-tert-Butyl Ester
CAS No.	1253200-82-6
Molecular Formula	C12H21NO4
Molecular Weight	243.30 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-6-methylpiperidine-3-carboxylic acid (cis-); cis-1-Boc-6-methylnipecotic acid; (3S,6R)-1-Boc-6-methylpiperidine-3-carboxylic acid; (3R,6S)-1-Boc-6-methylpiperidine-3-carboxylic acid; 6-Methyl-1,3-piperidinedicarboxylic acid 1-(1,1-dimethylethyl) ester (cis-); cis-6-Methyl-1-Boc-piperidine-3-carboxylic acid; tert-Butyl cis-6-methyl-3-carboxypiperidine-1-carboxylate
EINECS	Contact for details

Quality Control

Our cis-6-Methyl-Piperidine-1,3-Dicarboxylic Acid 1-tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical and chiral purity, meeting the stringent requirements for pharmaceutical R&D and scale-up. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (cis-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.