Description

1H-Pyrazole-1,3-Dicarboxylic Acid, 1-(1,1-Dimethylethyl) Ester is a high-purity, protected pyrazole-dicarboxylate derivative serving as a critical synthetic intermediate. This compound matters for its role in constructing complex heterocyclic scaffolds, enabling precise molecular assembly in advanced research and development. It is primarily needed by pharmaceutical and agrochemical R&D teams, as well as academic laboratories focused on medicinal chemistry and organic synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides and fungicides, leveraging the pyrazole core's bioactivity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized chelating ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of organic semiconductors and metal-organic frameworks (MOFs) due to its rigid, functionalizable structure.
• Peptidomimetics and PROTACs: The protected dicarboxylate group is valuable for constructing peptide analogs and Proteolysis Targeting Chimeras (PROTACs) in drug discovery.
• Academic & Contract Research: A versatile reagent for methodological studies in organic chemistry, including cross-coupling and cyclization reactions.

Basic Information

Product Name	1H-Pyrazole-1,3-Dicarboxylic Acid, 1-(1,1-Dimethylethyl) Ester
CAS No.	1252855-23-4
Molecular Formula	C10H14N2O4
Molecular Weight	226.23 g/mol
Synonyms	1-tert-Butyl 1H-pyrazole-1,3-dicarboxylate; 1-(tert-Butyl) 1H-pyrazole-1,3-dicarboxylate; Pyrazole-1,3-dicarboxylic Acid 1-tert-Butyl Ester; 1H-Pyrazole-1,3-dicarboxylic Acid 1-(1,1-Dimethylethyl) Ester; tert-Butyl Pyrazole-1,3-dicarboxylate; 1252855-23-4; 1-Boc-pyrazole-3-carboxylic acid (common misnomer); 1-(tert-Butoxycarbonyl)-1H-pyrazole-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our 1H-Pyrazole-1,3-Dicarboxylic Acid, 1-(1,1-Dimethylethyl) Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with research and development grade standards. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider inert gas purging to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.